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The ortho-toluene sulfonamide is divided while in the solvent of sulfonyl chloride, then oxidized to anthranilic acid, and after that heated and cyclized to be saccharin. Groups of 25 male and twenty five woman Charles River CD mice, 8 weeks of age, obtained diets made up of sodium saccharin (made up of 345 mg/kg (ppm) ortho-toluenesulfonamide) at

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